GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4888671 | 1 | rs57935196 | chr16:77785314 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.91 | 1.25E-6 | Obesity-related traits |
| THCA | cis | rs2274273 | 1 | rs57970196 | chr14:55600405 | KIAA0831 | chr14:55833110-55878576:- | -0.12 | -3.41 | 0.000709 | Protein biomarker |
| THCA | cis | rs7112513 | 1 | rs579890 | chr11:116798963 | PCSK7 | chr11:117075789-117102811:- | -0.32 | -5.46 | 7.62E-8 | Protein quantitative trait loci |
| THCA | cis | rs57994353 | 1 | rs57994353 | chr9:139356987 | INPP5E | chr9:139323075-139334256:- | -0.2 | -4.65 | 4.26E-6 | cutaneous squamous cell carcinoma |
| THCA | cis | rs57994353 | 1 | rs57994353 | chr9:139356987 | SDCCAG3 | chr9:139296375-139305054:- | -0.27 | -5.69 | 2.19E-8 | cutaneous squamous cell carcinoma |
| THCA | cis | rs614226 | 1 | rs580016 | chr12:120933977 | POP5 | chr12:121016849-121019201:- | 0.14 | 4 | 7.29E-5 | Type 1 diabetes nephropathy |
| THCA | cis | rs2786111 | 1 | rs580067 | chr1:197298373 | CFHR3 | chr1:196743930-196762872:+ | 0.25 | 5.22 | 2.73E-7 | Lupus nephritis in systemic lupus erythematosus |
| THCA | cis | rs8030605 | 1 | rs58036957 | chr15:56373056 | MNS1 | chr15:56720929-56757335:- | -0.25 | -3.7 | 0.00024 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs58036957 | chr15:56373056 | TEX9 | chr15:56657644-56738071:+ | -0.35 | -5.96 | 4.81E-9 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs17401966 | 1 | rs58053556 | chr1:10442903 | KIF1B | chr1:10270764-10441659:+ | 0.21 | 6.13 | 1.8E-9 | Hepatocellular carcinoma |
| THCA | cis | rs2129782 | 1 | rs58059872 | chr8:89451134 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs1027730 | 1 | rs58061411 | chr8:94077680 | C8orf83 | chr8:93895865-94029901:- | 0.28 | 4.45 | 1.07E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs2243480 | 1 | rs58062456 | chr7:65394852 | CCT6P1 | chr7:65216092-65228661:+ | 0.38 | 6 | 3.93E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs58062456 | chr7:65394852 | CRCP | chr7:65579805-65619551:+ | -0.26 | -4 | 7.24E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs58062456 | chr7:65394852 | RABGEF1 | chr7:66093890-66276446:+ | 0.55 | 6.89 | 1.73E-11 | Diabetic kidney disease |